AM-4030 is an analgesic drug which is a cannabinoid receptor agonist. It is a derivative of HU-210 which has been substituted with a 6β-((E)-3-hydroxyprop-1-enyl) group. This adds a \"southern\" aliphatic hydroxyl group to the molecule as seen in the CP-series of nonclassical cannabinoid drugs, and so AM-4030 represents a hybrid structure between the classical and nonclassical cannabinoid families, with the 6-hydroxyalkyl chain rigidified with a double bond with defined stereochemistry. This gives AM-4030 a greater degree of selectivity, so while it is still a potent agonist at both CB1 and CB2, it is reasonably selective for CB1, with a Ki of 0.7nM at CB1 and 8.6nM at CB2, a selectivity of around 12x. Resolution of the enantiomers of AM-4030 yields an even more potent compound, although with less selectivity, with the (−) enantiomer AM-4030a having a Ki of 0.6nM at CB1 and 1.1nM at CB2.
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{"slip": { "id": 121, "advice": "If you think your headphones are dying, check the socket for fluff with a straightened paperclip."}}
{"type":"standard","title":"Loop Creek (West Virginia)","displaytitle":"Loop Creek (West Virginia)","namespace":{"id":0,"text":""},"wikibase_item":"Q16894309","titles":{"canonical":"Loop_Creek_(West_Virginia)","normalized":"Loop Creek (West Virginia)","display":"Loop Creek (West Virginia)"},"pageid":41179518,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/7/73/Loop_Creek_WV.jpg/330px-Loop_Creek_WV.jpg","width":320,"height":240},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/7/73/Loop_Creek_WV.jpg","width":3648,"height":2736},"lang":"en","dir":"ltr","revision":"1273767332","tid":"384d886e-e282-11ef-bae8-1e6e9bace4e6","timestamp":"2025-02-03T22:57:19Z","description":"River in West Virginia, United States","description_source":"local","coordinates":{"lat":38.1278852,"lon":-81.2576092},"content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Loop_Creek_(West_Virginia)","revisions":"https://en.wikipedia.org/wiki/Loop_Creek_(West_Virginia)?action=history","edit":"https://en.wikipedia.org/wiki/Loop_Creek_(West_Virginia)?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Loop_Creek_(West_Virginia)"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Loop_Creek_(West_Virginia)","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Loop_Creek_(West_Virginia)","edit":"https://en.m.wikipedia.org/wiki/Loop_Creek_(West_Virginia)?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Loop_Creek_(West_Virginia)"}},"extract":"Loop Creek, also known by the spelling Loup Creek, is a tributary of the Kanawha River, 20 miles (32Â km) long, in southern West Virginia in the United States. Via the Kanawha and Ohio rivers, it is part of the watershed of the Mississippi River, draining an area of 49.6 square miles (128Â km2) in a coal mining region on the unglaciated portion of the Allegheny Plateau.","extract_html":"
Loop Creek, also known by the spelling Loup Creek, is a tributary of the Kanawha River, 20 miles (32Â km) long, in southern West Virginia in the United States. Via the Kanawha and Ohio rivers, it is part of the watershed of the Mississippi River, draining an area of 49.6 square miles (128Â km2) in a coal mining region on the unglaciated portion of the Allegheny Plateau.
"}